17th Annual Delsys Prize Winner

‘Empowering the EMG Signal Source’: Agonist-Antagonist Myoneural Interfaces for Neuroprosthetic Control 



Ms. Shriya Srinivasan

Harvard - MIT

United States

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Myoelectric prostheses today are fundamentally limited by the poor signal quality and lack of independence obtained from the muscles in amputated limbs. The regenerative Agonist-antagonist Myoneural Interface (AMI) reengineers the residual neuromuscular anatomy, to provide high SNR EMG signal sources and enable sensory feedback. 

By grafting muscles onto nerves, which are normally discarded during amputation, motor command signals are preserved, amplified and efficaciously interfaced to surface EMG sensors. Further, the AMI establishes flexor-extensor muscle pair relationships, which enables proprioceptive sensory feedback regarding the position, velocity and impedance of a prosthesis to be communicated to the user. By sculpting human physiology to better meet the needs of EMG-based devices, the AMI greatly advances myoelectric control. 

"It's an honor to be recognized by the De Luca foundation with the 2019 Delsys Prize. In furthering Prof. De Luca's goals towards integrating neurophysiology, biomechanics, and electromyography, I hope my efforts will help make myoelectric prosthetic control the standard for patients in the near future.”

About Ms. Srinivasan

Ms. Shriya Srinivasan

Shriya is a doctoral candidate studying biomedical engineering at the Harvard-MIT Health Sciences and Technology program. Her current research in Dr. Hugh Herr's Biomechatronics group at the MIT Media Lab, synthesizes her medical and engineering training to redesign the surgical paradigm for amputation.

Using regenerative muscle grafts, Shriya has developed a method that enables improved neural interfacing with advanced biomechatronic devices as well as returns sensory feedback from prostheses. Notably, her methods can be applied to persons who have already undergone amputation, restoring lost function to severed nerves.

Shriya's work has been featured on NPR's Science Friday, Harvard Medicine Magazine, and other notable outlets.

Shriya was the former co-director of MIT Hacking Medicine and led initiatives that have educated individuals in design thinking principles, jumpstarted entrepreneurial efforts in low-resource settings, and nurtured healthcare innovation efforts.